The main 205-hectare campus houses colleges of engineering, agriculture, chemistry, architecture, paediatric medicine, humanities, science, social science, economics and sports science.

Since 2018 it has acted as 'founder' of D-8 International University, an intergovernmental institution for exchange students from Iran, Turkey, Egypt, Nigeria, Bangladesh, Malaysia, Pakistan and Indonesia.

Mansor Gholami, chancellor from 1994 to 19 to 2017, went from his second term to become minister of science with responsibilities including higher education. Its first chancellor was Akbar Etemad, a native of Hamedan often described as the father of Iran’s nuclear programme, whose next job was deputy prime minister. It was founded in 1975 with both assistance and advice from the government of France and has continued to be marked by high politics. It was named after Buali Sina, also known as Avicenna, an 11th century Muslim polymath who has been called 'the father of modern medicine', Bu-Ali Sina University is a state institution in Hamedan, the capital of the Iranian province of the same name.

Tibbe bu ali sina pdf